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. Author manuscript; available in PMC: 2021 Nov 4.
Published in final edited form as: Nat Metab. 2021 Jan 4;3(1):21–32. doi: 10.1038/s42255-020-00317-z

Figure 3. The metabolic cross-talk between tumor cells and immune or stromal cells within the TME.

Figure 3.

The metabolite composition of the TME is shaped by stromal and immune cells, each with unique metabolic profiles, dependencies, and vulnerabilities compared to tumor cells. Here we depict the metabolic interactions of T cells (blue), macrophages (red) or stromal cells (green) with tumor cells (brown) in the TME. Yellow arrows indicate upregulation.