FIG 1.

Phylogenomic analysis of 12 kitten aEPEC isolates associated with nonclinical colonization (NC) or lethal (LI) infections compared with a previously sequenced collection of 149 aEPEC genomes and 49 diverse E. coli and Shigella reference genomes. The kitten aEPEC genomes are indicated by blue (NC) and orange (LI) labels. The previously described EPEC phylogenomic lineages (22, 38) are indicated with gray shading, and the lineage reference genomes are in boldface font. The E. coli and Shigella phylogroups (A, B1, B2, D, E, and F) are indicated in the interior of the phylogeny. Bootstrap values ≥80 are indicated by gray circles. The scale bar indicates the approximate distance of 0.06 changes per site.