FIG 2.
Innate lymphocytes (ILCs) are essential for systemic bacterial control and prolonged survival of Rag1-deficient mice. B6, Rag1−/−, and Rag2−/− γc−/− mice were infected intravaginally with 1 × 105 C. muridarum organisms. (A) Survival. (B) Body weight. (C) Bacterial burdens in vaginal swabs, rectal swabs, and systemic organs determined at 12 days postinfection. Data shown are combined results of two independent experiments with 9 or 10 mice per group (A) or representative results of two independent experiments with 3 to 5 mice per group in each experiment (B and C). Each data point represents an individual mouse. Bars and error bars represent means and standard errors of the means (SEM). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.