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. 2021 Feb 11;38(5):2014–2029. doi: 10.1093/molbev/msab003

Fig. 5.

Fig. 5.

Representative proteins involved in different processes like DNA replication, transcription, translation, DNA repair, and genome packaging of Mimiviridae family viruses show an evidence of coevolution. (A) A matrix of correlation coefficients of proteins shown as a heatmap and (B) the MDS analysis of the same set of proteins showing the cluster of proteins in 2D space. DNA polymerase (gp351), putative helicase (gp229), DNA topoisomerase 2 (gp515), putative serine/threonine-protein kinase (gp254), probable uracil-DNA glycosylase (gp271), putative DNA mismatch repair protein MutS-like protein (gp389), DNA-directed RNA polymerase subunit 2 (gp266), ribonucleoside-diphosphate reductase large subunit (gp342), putative translation initiation factor 4a (gp492), DNA-directed RNA polymerase subunit 1 (gp540), uncharacterized hydrolase (gp597), and A32 virion packaging ATPase (gp468).