Fig. 6.

Folding stability of Pax9 intronic sequences as a proxi of activators in the inhibitory cascade model. Dot plots, Spearman correlations (rho), and linear association (R2) of M2md/M1md ratio and the A/I model given by the formula Mx/M1 = 1 + [(a—i)/i] (x-1), where for each tooth position (x), (a) represents the relative strength of activators, and (i) the inhibitors. The ratio between mesiodistal length of M1 (M1md) and of secondary palate (M1md/Pal2) was used as an estimate of inhibitory effect (i) and nMfe the activator (a). (A) Associations between M2md/M1md and control (nMfe replaced by 1). (B) Associations obtained between M2md/M1md and the formula output using Seq1Seq2 nMfe as activator. (C) and (D) represent the associations shown on (A) and (B) using phylogenetically independent contrasted data, respectively. Note that the use of Seq1Seq2 nMfe as activator (B, D) resulted in improved correlations and linear associations when compared with their respective controls (A, C).