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. 2021 Mar 1;8(9):2004793. doi: 10.1002/advs.202004793

Figure 5.

Figure 5

Mechanism for chondrocytes degradation protection of the nanosystem. a) The qRT‐PCR analysis exhibiting the mRNA expression of IL‐1β in chondrocytes treated with 10 mU of H2O2 at different concentrations of SNAs (0, 5, 10, 20, and 50 µg mL−1). n = 3, **p < 0.01, ***p < 0.001, compared with control; ## p < 0.01, ### p < 0.001, compared with blank group. qRT‐PCR analysis and quantitation of b) Col2α, c) aggrecan, d) MMP‐1, and e) MMP‐13 expression in chondrocytes treated with 10 mU of H2O2, and cocultured with HA, SNAs, HA‐SNAs, HA‐SNAs+NIR for 24 h. f) Western blot analysis and quantitation of g) Col2α, h) aggrecan, i) MMP‐1, and j) MMP‐13 expression in chondrocytes treated with 10 mU of H2O2, and cocultured with HA, SNAs, HA‐SNAs, HA‐SNAs+NIR for 24 h. n = 3, *p < 0.05, **p < 0.01, ***p < 0.001, compared with control; # p < 0.05, ## p < 0.01, ### p < 0.001, compared with blank group.