Table 1.

Annotated regulatory domains of DNMTs and associated proteins.

Gene (‐Domain)	Interaction	Location	Functional significance
DNMT1‐ RFTS	H3K18ub (+) H3K23ub (+)	Replication fork	Maintenance methylation
DNMT1‐ RFTS	H3K9me3 (+)	Heterochromatin	Maintenance methylation
UHRF1‐TTD/PHD	H3K9me3 (+)	Heterochromatin	Replication‐uncoupled maintenance methylation
UHRF1‐PHD	H3R2me2a (−)	Active genes	Prevent aberrant maintenance methylation
DNMT3L/A/B‐ADD	H3K4me3 (−)	Active gene promoter	Prevent aberrant de novo methylation
DNMT3B‐PWWP	H3K36me3 (+)	Active gene body	Genic de novo methylation
DNMT3A‐PWWP	H3K36me2 (+)	Intergenic region	Intergenic de novo methylation