Figure 2. Parp1 hyperactivation triggers juvenile seizures and mortality in the absence of Xrcc1.

1. Kaplan–Meier curves for survival of mice of the indicated genotypes. The table shows number of individuals in each group, median survival (weeks) and P‐values from pairwise curve comparisons; Und: undetermined (log‐rank Mantel–Cox tests).
2. Video monitoring and recording of generalized running/bouncing seizures in mice of the indicated genotypes from P15‐P19. The point of death of Xrcc1^Nes‐Cre mice by fatal seizure is indicated (cross). Note no seizures from mice of other genotypes were detected. WT (n = 9 mice), Xrcc1^Nes‐cre (n = 3 mice), Parp1^+/−/Xrcc1^Nes‐Cre (n = 3 mice) and Parp1^−/−/Xrcc1^Nes‐Cre (n = 3).