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. 2021 May 1;22(5):e51851. doi: 10.15252/embr.202051851

Figure 3. Suppression of seizure‐like activity in Xrcc1Nes‐Cre brain slices by Parp1 deletion.

Figure 3

  1. Plots of enveloped spike activity waveforms based on targeted extracellular recordings from hippocampal CA3 region perfused into epileptogenic buffer for the indicated genotypes. Upward deflections indicate seizure‐like episodes (SLEs). Scale bars, 5% of maximum amplitude.
  2. Heatplots of cumulative SLEs: WT (n = 11 slices from three mice), Xrcc1Nes‐Cre (n = 12 slices from four mice), Parp1+/−/Xrcc1Nes‐Cre (n = 12 slices from three mice) and Parp1−/−/Xrcc1Nes‐Cre (n = 10 slices from three mice). Each horizontal bar corresponds to one slice with the colour code indicating cumulative SLEs.
  3. Summary of mean ± SEM cumulative SLE counts. The number of replicates was the same as in (B). At the recording endpoint, the total SLE count in Xrcc1Nes‐Cre is significantly higher than both WT and Parp1−/− Xrcc1Nes‐Cre (Kruskal–Wallis ANOVA, P < 0.0017, * indicates significance with Dunn’s post hoc comparisons).