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. 2021 Mar 18;22(5):e51280. doi: 10.15252/embr.202051280

Figure 3. Deletion of Tlr4 in a murine ear outer hair cell line (HEI‐OC1) reduces cisplatin‐induced ototoxic responses.

Figure 3

  • A–D
    HEI‐OC1 cells containing a Tlr4 deletion (Tlr4 −/−) were compared to HEI‐OC1 non‐targeting (NT) control cells and assessed for cell viability (A), Annexin V/propidium iodide staining (B), ROS generation (C), and IL‐6 secretion (D) following cisplatin treatment at the indicated concentrations (n = 3 independent biological replicates).

Data Information: In all panels, data are presented as mean and standard deviation. Statistical comparisons to NT at the same cisplatin concentration were assessed by 2‐way (A, B) or one‐way (C, D) ANOVA. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (Bonferroni test).

Source data are available online for this figure.