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. 2021 Mar 18;22(5):e51280. doi: 10.15252/embr.202051280

Figure 4. Cisplatin has a primary role in Tlr4 activation in HEI‐OC1 cells.

Figure 4

  1. IL‐6 secretion in HEI‐OC1 cells treated with 100 pg/ml LPS or 20 µM cisplatin (n = 3 or 4 independent biological replicates).
  2. IL‐6 secretion in TLR4−/− cells transfected with empty vector (EV) or mouse Tlr4 (mTlr4) following treatment with 20 µM cisplatin (n = 6 independent biological replicates).
  3. Il6 and Tlr4 transcript levels in HEI‐OC1 cells following treatment with 20 µM cisplatin for the indicated times (n = 3 independent biological replicates).

Data information: In all panels, data are presented as mean and standard deviation. Statistical comparisons to 0 h time point were assessed by 2‐way ANOVA. ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (Dunnett’s test).

Source data are available online for this figure.