Figure 5. Zebrafish Tlr4 mediates cisplatin‐induced ototoxicity in vivo .

1. Hair cell viability in larval zebrafish (assessed by DASPEI staining) following cisplatin treatment at the indicated concentrations.
2. Hair cell viability in larval zebrafish pre‐treated with control‐, tlr4ba‐, and/or tlr4bb‐targeting morpholino oligonucleotides (MO) and subsequently treated with 15 µM cisplatin.

Data information: In both panels, each data point represents a score of hair cell integrity in an individual animal (taken from multiple samples per animal) with lines representing mean and standard deviation. Statistical comparisons between cisplatin concentrations (A) or to control morpholino (B, except as indicated in blue) were assessed by one‐way ANOVA. *P < 0.05; **P < 0.01; ****P < 0.0001 (Tukey test).

Source data are available online for this figure.