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. 2021 Mar 18;22(5):e51280. doi: 10.15252/embr.202051280

Figure 6. Small molecule inhibition of Tlr4 mitigates cisplatin‐induced ototoxic responses in HEI‐OC1 cells.

Figure 6

  1. IL‐6 secretion in HEI‐OC1 cells pre‐treated with DMF vehicle (veh), 4 µM TAK242 (TAK), or left untreated (nil) following treatment with 10 ng/ml LPS or 20 µM cisplatin (n = 5–7 independent biological replicates).
  2. ROS generation in HEI‐OC1 cells pre‐treated with DMF vehicle (veh), 4 µM TAK242 (TAK), or left untreated (nil) following treatment with 20 µM cisplatin (n = 3 independent biological replicates).

Data Information: In all panels, data are presented as mean and standard deviation. Statistical comparisons to nil treatment were assessed by 2‐way (A) or one‐way (B) ANOVA. *P < 0.05; **P < 0.01; ****P < 0.0001(Dunnett’s test).

Source data are available online for this figure.