Figure 2.

3‐HB treatment reduces murine atherogenesis. A,B) Representative images of en face Oil Red O stained aortas and quantification of aortic plaque burden of mice treated with or without 3‐HB (100 mg kg⁻¹ d⁻¹) and NA (100 mg kg⁻¹ d⁻¹), respectively (n = 7 per group). C,D) Representative images and quantification of aortic root lesion areas and plaque compositions. Movat staining measurement of aortic lesion areas (n = 7); CD68 immuno‐histochemical staining measurement of macrophage content (n = 7); Oil Red O staining measurement of lipid content (n = 7). Scale bar = 200 µm. Data were presented as the mean±SEM from at least three independent experiments, one‐way ANOVA, * p < 0.05, and ** p < 0.01.