Figure 7.

3‐HB attenuates atherosclerosis dependent on the Gpr109a expressing bone‐marrow‐derived macrophages. WT and Gpr109a ^−/− bone marrow chimeric mice were intragastric administrated with 3‐HB or without 3‐HB (100 mg kg⁻¹ d⁻¹) for 9 weeks. A,B) Representative images and quantitative analysis of lesion areas, Masson measurement of lesion areas (n = 7). C,D) Representative images and quantitative analysis of lipid deposition, respectively. Oil Red O staining measurement of lipid content (n = 5). Results were presented as mean±SEM from at least three independent experiments, Student's t‐test, * p< 0.05, ** p < 0.01.