Figure 6.

Schematic representation of the functional mechanisms of MgFe‐LDH nanoparticles in regulating mESC pluripotency. MgFe‐LDH nanoparticles can activate the LIFR/PI3K/AKT and LIFR/JAK/STAT3 signaling pathways, resulting in downstream TET1/2 expression promoted by the activated p‐STAT3 thus controlling the expression of pluripotency‐related genes and DNA demethylation. In addition, Fe²⁺ released from MgFe‐LDH nanoparticles also proves beneficial in enhancing TET expression. All the above mechanisms ultimately make MgFe‐LDH an excellent substitute for LIF in maintaining mESC pluripotency.