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. 2021 Mar 1;8(9):2004632. doi: 10.1002/advs.202004632

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© 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Three NAD⁺ de novo biosynthesis pathways. The enzymes used in this work are in parenthesis and color‐coded as either red (from secondary metabolic processes like natural product biosynthesis and aromatic compound degradation) or blue (from NAD⁺ biosynthesis). ADIC: 2‐amino‐2‐deoxyisochorismate; DHHA: 2,3‐dihydro‐3‐hydroxyanthranilic acid; ACMS: 2‐amino‐3‐carboxymuconate semialdehyde; 3‐HAA: 3‐hydroxyanthranilic acid; PRPP: 5‐phosphoribosyl diphosphate; NAMN: nicotinic acid mononucleotide; NAAD: nicotinic acid adenine dinucleotide.