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. 2021 Mar 18;65(4):e01839-20. doi: 10.1128/AAC.01839-20

TABLE 1.

MICs of itraconazole, voriconazole, bifonazole, fluconazole, terbinafine, and amphotericin B for sltA mutantsa

Strain MIC (μg ml−1)
ITZ VRC Bifo Flu Terb AMB
WT 1 0.5 4 200 8 8
ΔsltA 0.5 0.25 2 100 4 8
sltAC 1 0.5 4 200 8 8
C502S 0.5 0.25 2 100 4 8
H518A 0.5 0.25 2 100 4 8
SltAΔC 0.5 0.25 2 100 4 8
OE::sltA 2 1 6 250 16 8
R243Qb 4 2 8 NT >16 8
R243Q ΔsltA 2 0.5 4 NT 8 8
Shjt40c 4 2 16 NT 16 8
Shjt40 ΔsltA 2 1 8 NT 8 8
Shjt42bc >8 2 >16 NT >16 8
Shjt42b ΔsltA 4 1 8 NT 16 8
a

ITZ, itraconazole; VRC, voriconazole; Bifo, bifonazole; Terb, terbinafine; AMB, amphotericin B; Flu, fluconazole; C502S, SltAC502S; H518A, SltAH518A; R243Q, Cox10R243Q (38); NT, not tested.

b

Laboratory-derived isolate resistant to itraconazole.

c

Clinical isolate resistant to itraconazole (39).