TABLE 2.
Difference in QT intervals by various correction methods from the baseline
| Measurement (day peak − day 0) | Data for treatment group: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All |
AL+a |
ASMQ |
DP |
CHQ |
||||||
| Total | Mean (SD) or % (no. of women) | Total | Mean (SD) or % (no. of women) | Total | Mean (SD) or % (no. of women) | Total | Mean (SD) or % (no. of patients) | Total | Mean (SD) or % (no. of patients) | |
| ΔQT uncorrected (ms) | 245 | 34.5 (26.4) | 79 | 32.0 (27.4) | 73 | 29.6 (27.0) | 77 | 41.4 (23.2) | 16 | 36.3 (23.9) |
| QT >30 ms | 245 | 64.5% (158) | 79 | 62.0% (49) | 73 | 53.4% (39) | 77 | 76.6% (59) | 16 | 68.8% (11) |
| QT >60 ms | 245 | 19.6% (48) | 79 | 12.7% (10) | 73 | 21.9% (16) | 77 | 24.7% (19) | 16 | 18.8% (3) |
| Δ QTc Fridericia (ms) | 245 | 15.84 (20.9) | 79 | 9.76 (18.9) | 73 | 9.02 (19.9) | 77 | 26.6 (20.0) | 16 | 25.3 (14.5) |
| QTc Fridericia >30 ms | 245 | 23.3% (57) | 79 | 10.1% (8) | 73 | 16.4% (12) | 77 | 40.3% (31) | 16 | 37.5% (6) |
| QTc Fridericia >60 ms | 245 | 1.6% (4) | 79 | 0.0% (0) | 73 | 0.0% (0) | 77 | 5.2% (4) | 16 | 0.0% (0) |
| Δ QTc Bazett (ms) | 245 | 4.58 (24.96) | 79 | −3.54 (23.4) | 73 | −3.45 (23.0) | 77 | 17.6 (22.9) | 16 | 18.7 (18.7) |
| QTc Bazett >30 ms | 245 | 15.5% (38) | 79 | 7.6% (6) | 73 | 5.5% (4) | 77 | 31.2% (24) | 16 | 25.0% (4) |
| QTc Bazett >60 ms | 245 | 1.2% (3) | 79 | 0.0% (0) | 73 | 0.0% (0) | 77 | 2.6% (2) | 16 | 6.3% (1) |
| Δ QTcP (ms) | 245 | 12.7 (21.5) | 79 | 6.11 (19.5) | 73 | 5.60 (20.2) | 77 | 24.1 (20.4) | 16 | 23.5 (15.0) |
| QTcP >30 ms | 245 | 19.6% (48) | 79 | 10.1% (8) | 73 | 8.2% (6) | 77 | 36.4% (28) | 16 | 37.5% (6) |
| QTcP >60 ms | 245 | 1.6% (4) | 79 | 0% (0) | 73 | 0% (0) | 77 | 5.2% (4) | 16 | 0% (0) |
a
AL+, extended artemether-lumefantrine; ASMQ, artesunate-mefloquine; CHQ, chloroquine; Δ, difference; DP, dihydroartemisinin-piperaquine; QTc Fridericia, QT interval corrected by Fridericia method; QTc Bazett, QT interval corrected by Bazett method; QTcP, QT interval corrected by population-based correction (QT/RR0.381).