FIG 1.
Putative pathway for metabolism of AT-527 to its active triphosphate, AT-9010. Enzymes likely involved in the metabolic pathways include cathepsin A (CatA), carboxylesterase 1 (CES1), histidine nucleotide triad 1 (HINT1), adenosine deaminase-like protein 1 (ADALP1), guanidylate kinase 1 (GUK1), nucleoside diphosphate kinase (NDPK), and 5′-nucleotidase (5′-NTase).