FIG 3.

Plasma profiles of AT-511 and its metabolites in nonhuman primates after oral doses of AT-527. Cynomolgus monkeys (n = 3) were orally administered a loading dose of 60 mg/kg AT-527 followed by 30 mg/kg maintenance doses every 12 h for 3 days to achieve steady state. Blood was collected preceding and at 0.5, 1, 2, 4, 6, 8, and 12 h after the 5th dose, and plasma AT-511, AT-551, and AT-273 concentrations were determined by LC-MS/MS. Data are expressed as means ± SEs.