FIG 4.
Tissue concentrations of AT-9010 in nonhuman primates. Cynomolgus monkeys were given a loading dose of 60 mg/kg AT-527 followed by 30 mg/kg maintenance doses every 12 h for 3 days to achieve steady state. Tissue samples were collected under anesthesia at the indicated time points after the last dose, flash frozen, and homogenized, and AT-9010 concentrations were determined by LC-MS/MS. Data are expressed as means ± SEs (n = 3).