FIG 5.

Probabilities of EI₉₉ target attainment for 5,000 simulated patients infected with A. fumigatus isolates with different CLSI echinocandin MECs and treated with various caspofungin, anidulafungin, and micafungin doses once daily. The CLSI epidemiological cutoff value (ECV) of caspofungin (16) and minimum effective concentration (MEC) values for 90% of isolates tested (MEC₉₀) of anidulafungin and micafungin (17) against A. fumigatus are shown. The lowest anidulafungin and micafungin concentration tested for the determination of CLSI MEC distribution was 0.008 mg/liter (*) (17).