TABLE 2.
Exposure indices associated with 50 to 99.9% (EI50-EI99.99) of maximal activity estimated for each echinocandin and susceptibility testing method based on the Emax model
| Druga | Methodb | Mean (95% confidence interval) PK/PD index (fAUC0–24/MEC) associated with: |
|||||
|---|---|---|---|---|---|---|---|
| EI10 | EI50 | EI90 | EI99 | EI99.9 | EI99.99 | ||
| AFG | CLSI | 47 (37–60) | 116 (109–125) | 287 (232–354) | 766 (494–1,188) | 1,977 (1,020–3,832) | 5,083 (2,028–12,317) |
| EUCAST | 24 (19–30) | 58 (54–62) | 143 (116–177) | 383 (247–594) | 988 (510–1,916) | 2,541 (1,049–6,158) | |
| CAS | CLSI | 1.9 (1.3–2.8) | 3.2 (2.8–3.5) | 5.2 (3.6–7.4) | 8.8 (4.3–18.2) | 14.8 (5.1–43.6) | 24.8 (5.9–104) |
| EUCAST | 1.0 (0.7–1.4) | 1.6 (1.4–1.8) | 2.6 (1.8–3.7) | 4.4 (2.2–9.1) | 7.4 (2.5–21.8) | 12.4 (3.0–52.2) | |
| MFG | CLSI | 6.0 (4.5–8.4) | 15.8 (13.9–18.0) | 40.8 (33.2–50.2) | 115 (74.1–179) | 312 (158–616) | 843 (336–2,120) |
| EUCAST | 3.0 (2.4–4.0) | 8.2 (7.4–9.2) | 22.2 (18.4–26.7) | 65.3 (44.3–96.3) | 185 (102–335) | 521 (234–1,162) | |
a
AFG, anidulafungin; CAS, caspofungin; MFG, micafungin.
b
Broth microdilution.