FIG 5.

Parasite clearance across the murine and human experiments after single-dose treatment with OZ439. Within one experimental system, the predicted clearance rates are fairly consistent. (a) Model c (compensatory erythropoeisis) of P. berghei-NMRI infection estimated a lower maximum drug effect E_max resulting in lower clearance rates (see Table S5 in the supplemental material). (b) Compared to panels a and c, P. falciparum-SCID infection shows less variability. (c) The wide clearance range observed in model predictions of the exponential growth model i for P. falciparum-human infection stems from the wide posterior distribution of the maximum drug effect E_max. Parasite clearance rates were calculated from simulation output using the methodology provided previously (49). For comparability, a conversion to log₁₀ PRR₄₈ was added as a secondary y axis where log₁₀ PRR₄₈ = log₁₀(e^{parasite clearance rate ×48}).