TABLE 2.

Classification of model parameters into host, parasite, host-parasite, and drug parameters^a

Parameter	Model parameter(s)
	P. berghei-NMRI	P. falciparum-SCID	P. falciparum-human
Host		Initial percentage of human RBCs H0; base death rate of all RBCs λ; Parameters of RBC density dependent RBC clearance χmax and kχ50	Parasite death rate at each time stage δp
Parasite	Infectivity parameter β; no. of merozoites per infected RBC r; attraction of parasite to reticulocyte ε; parasite inoculum viability ω	Infectivity parameter β; no. of merozoites per infected RBC r; parasite inoculum viability ω; expt parasite growth rate rp; initial parasitemia P0	Intrinsic parasite multiplication rate rp; distribution parameters of the initial parasite density μipl and σipl
Host- parasite	Parameters of infection-induced RBC clearance γmax and kγ50; conc. of infected mouse RBCs achieving 0.5 growth retardation effect kl,50	Parameters of infection-induced RBC clearance γmax and kγ50; base clearance of infected RBCs φ	Initial parasite density ipl
Drug	Parameters of concn effect relationship Emax, EC50; clearance rate for damaged parasites CLY; first-order rate constant for biological intermediate kR	Parameters of concn effect relationship Emax, EC50; clearance rate for damaged parasites CLY; first-order rate constant for biological intermediate kR	Parameters of concn effect relationship Emax, EC50; growth retardation parameter kret

^aParameters were classified based on their dependency on host and parasite variable states and induction through those variables. Detailed description of parameters for murine models of P. berghei-NMRI and P. falciparum-SCID infection can be found in reference 15. Details on parameters of P. falciparum-human infection can be found in Fig. 2 and Table 3.