TABLE 3.

Parameters of the parasite growth and treatment models^a

Parameter	Unit	Description	Bounds [lower, upper]
ipl	parasites/ml	Parasite density 4 days after inoculation (log transformed)	[1, 15]
μipl	h	Mean of the initial parasite age distribution	[5, 10]
σipl	h	SD of the initial parasite age distribution	[2, 20]
δp	1/h	Drug-independent parasite death rate	[0.001, 1]
rp		Parasite replication rate	[40, 80]
αl	h	Length of the parasite life cycle	Fixed to 39 h
αs	h	Sequestration age of asexual parasites	Fixed to 25 h
pmf		Parasite multiplication factor
EC50	mg/ml	Drug concn causing 50% of Emax	MMV048, [0.001, 0.8]; OZ439, [1E-6, 0.1]
Emax	1/h	Maximum effect of the drug	[0.0001, 1]
γ		Hill coefficient, steepness of the CE curve
kret	1/h	Growth retardation due to drug treatment
kret,max	1/h	Maximum growth retardation	[0.0001, 1]

^aThe bounds for parameter estimation were set to include all plausible values based on previously published models (28, 30–32).