TABLE 2.

Antibiotics experimental concentrations and rationales

Antibiotic	Concn (mg/liter)	Rationalea
Daptomycin	30	$\frac{{\text{AUC}}_{0-24\text{\hspace{0.17em}h}}}{24\text{\hspace{0.17em}h}}$
Doxycycline	1.5	$\frac{{\text{AUC}}_{0-24\text{\hspace{0.17em}h}}}{24\text{\hspace{0.17em}h}}$
Linezolid	5	Cminb
Moxifloxacin	1.5	$\frac{{\text{AUC}}_{0-24\text{\hspace{0.17em}h}}}{24\text{\hspace{0.17em}h}}$
Rifampin	2.5	$\frac{{\text{AUC}}_{0-24\text{\hspace{0.17em}h}}}{24\text{\hspace{0.17em}h}}$
Vancomycin	2	Target trough concn (20 mg/liter)
Ceftazidime	3.8	Cmin
Ciprofloxacin	1.625	$\frac{{\text{AUC}}_{0-24\text{\hspace{0.17em}h}}}{24\text{\hspace{0.17em}h}}$
Colistin	2.5	$\frac{{\text{AUC}}_{0-24\text{\hspace{0.17em}h}}}{24\text{\hspace{0.17em}h}}$
Meropenem	0.25	Cmin

^aPharmacokinetic and PK/PD information obtained from the EUCAST rationales for clinical breakpoint documents or from the literature (references in Table S1 in the supplemental material).

^bC_min, minimum concentration of drug in serum.