FIG 3.

Incorporation of radiolabeled precursors into ubiquinones. RP-HPLC metabolic profiles of erythrocytes infected with P. falciparum schizonts incubated with different radiolabeled metabolites, as indicated. In all experiments, the samples were co-injected with UQ standards. The fractions were collected at 0.75 min. Glucose, [¹⁴C-U] Glc; SAM, [methyl-³H] SAM; FPP, [³H] FPP; 4-HB, [ring-¹⁴C]-4-HB; UQ-8, ubiquinone-8; UQH₂-8, ubiquinol-8; UQ-9, ubiquinone-9; UQH₂-9, ubiquinol-9. These experiments were performed twice for each radiolabeled precursor and all experiments yielded similar results.