FIG 8.
4-Nitrobenzoate enhances atovaquone efficacy. AV IC50 values (mean of three identical experiments with four technical replicates each). Assays were performed at 48 h in the presence of 1, 0.5, or 0.25 mM 4-nitrobenzoate (4-NB) or 0.5 mM 4-NB + 0.5 mM 4-hydroxybenzoate (4-HB). In the table, the individual FIC values for AV are presented. The results are depicted by bars that indicate the deviations. Results were analyzed by one-way analysis of variance (ANOVA)/Dunnet’s multiple comparison test. *, P < 0.05, **, P < 0.01, ***, P < 0.001.