TABLE 2.

Frequency and predicted relevance of mutations in relevant efflux-regulating genes

Gene	Mutation in proteina	SNAP2 scoreb	No. of mutations in:
			EEP isolates (n = 17)	Control strains (n = 17)
acrR	G28R	89	1	0
	V29G	72	4	0
	H115Y	1	1	0
	P155L	31	1	0
	T213I	–12	4	1
	N214T	–54	4	1
	*216YP*		0	1
	Frameshift		4	1
marA	S127N	60	3	12
marR	S3N	–90	1	0
	A53E	–35	2	0
	K62R	–66	4	0
	G103S	–74	11	16
	D118N	10	1	0
	Y137H	12	11	16
	Frameshift		1	0
soxR	T38S	–49	6	1
	G74R	−2	8	14
	A111T	–13	3	1
	G121D	68	1	0
rob	Q20H	–92	1	0
	A171S	–96	1	0
	A201_L202insSc		2	0
	I287T	26	0	1
acrS	H27R	–57	4	0
	E75D	–76	2	12
	E131D	–33	0	1
	R141H	−28	2	1
	A146G	−56	4	0
	V153I	–90	6	1
	D167N	33	2	1
	H212R	−15	2	0
	Q213K	−39	6	12
	T214A	−38	0	1
	M220I	5	8	13
	Q74*		1	0
	Deletion		1	2

^aAsterisks denote a stop codon.

^bSNAP2 scores were calculated as detailed in Materials and Methods. No prediction was possible for frameshifts, insertions, deletions, and stop codon mutations.

^cA201_L202insS denotes an insertion of serine between A201 and L202.