TABLE 3.

Multivariate comparison of expression levels of efflux-related genes

Gene	PI of EEP isolate vs control strain (95% CI)a	FDR Pb	Raw Pc	P (MANOVAd)
acrB	0.95 (0.81, 0.99)	<0.001	<0.001	<0.001
acrD	0.58 (0.39, 0.75)	0.503	0.447	0.227
acrF	0.24 (0.12, 0.43)	0.018	0.006	0.006
mdfA	0.44 (0,27, 0,63)	0.532	0.532	0.705
macB	0.60 (0,41, 0,76)	0.408	0.317	0.317
mdtK	0.80 (0.61, 0.91)	0.009	0.002	0.006
tolC	0.72 (0.50, 0.84)	0.047	0.026	0.029
mdtB	0.39 (0.21, 0.56)	0.408	0.285	0.280
mdtF	0.27 (0.13, 0.45)	0.045	0.020	0.033

^aPI, probabilistic index. PIs greater than 0.56, 0.64, or 0.70 (and, conversely, below 0.44, 0.36, or 0.30) were deemed to denote a small, medium, or large relative effect, respectively. CI, confidence interval. PIs and corresponding CIs were calculated using nonparametric testing as described in Materials and Methods.

^bFDR, false-discovery rate. FDR-corrected P values are from analysis of variance (ANOVA)-type post hoc analyses.

^cRaw P values are from ANOVA-type post hoc analyses not accounting for multiple testing.

^dMANOVA, multivariate analysis of variance testing, reported for comparison.