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Production of TNF-α by RAW 264.7 cells after incubation with carvacrol (CAR) (A) and thymol (THY) (B) for 24 and 48 h. LPS, 1 μg/ml. Results indicate the mean ± SEM of three measurements from three independent experiments. *, P < 0.05, ****, P < 0.0001. Differences were considered between nanoparticles and 32 μg/ml nonencapsulated phytocompound at 24 or 48 h of incubation, respectively.
