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Screening and IC50 measurements of the 3CLpro inhibitors. (A to C) The IC50 values of FDA-approved drugs, tolcapone, levothyroxine, and manidipine-2HCl, were measured to be 7.9 ± 0.9, 19.2 ± 1.2, and 10.4 ± 1.6, respectively, based on the inhibitor concentration-dependent curves.
