TABLE 1.
Cleavage rates of the peptides by SARS-CoV-2 3CLpro and PLpro
| Protease | Peptide | Cleavage rate (μM/s) |
|---|---|---|
| SARS-CoV-2 3CLpro | TSAVLQSGFRKM | 1.60 ± 0.12 |
| SGVTFQSAVKRT | 0.12 ± 0.03 | |
| KVATVQSKMSDV | 0.03 ± 0.005 | |
| NRATLQAIASEF | 0.07 ± 0.02 | |
| SAVKLQNNELSP | 0.02 ± 0.003 | |
| ATVRLQAGNATE | 0.15 ± 0.011 | |
| REPMLQSADAQS | 0.03 ± 0.01 | |
| PHTVLQAVGACV | 0.05 ± 0.012 | |
| NVATLQAENVTG | 0.01 ± 0.005 | |
| TFTRLQSLENVA | 0.11 ± 0.015 | |
| FYPKLQSSQAWQ | 0.26 ± 0.02 | |
| SARS-CoV-2 PLpro | RELNGGAYTRYV | 0.003 ± 0.001 |
| FTLKGGAPTKVT | 0.09 ± 0.012 | |
| IALKGGKIVNNW | 0.01 ± 0.004 |