TABLE 2.
Benznidazole pharmacokinetic parameters after single-oral-dose administration of 2.5 mg/kg BNZ alone or with E1224
| Treatmenta | Result for parameterb: |
||||
|---|---|---|---|---|---|
| Cmax, ng/ml | AUC0–t, ng · h/ml | AUC0–∞, ng · h/ml | t1/2, h | tmax, h | |
| BNZ (n = 28) | GM, 3,364 (CV%, 26.4) | GM, 70,559 (CV%, 32.0) | GM, 72,720 (CV%, 32.7) | GM, 12.2 (CV%, 25.2) | Median, 3.0 (range, 1.0–6.0) |
| BNZ + E1224 (n = 28)c | GM, 3,221 (CV%, 25.7) | GM, 59,299 (CV%, 29.8) | GM, 61,162 (CV%, 29.8) | GM, 10.0 (CV%, 19.4) | Median, 3.0 (range, 1.0–6.0) |
| BNZ + E1224 vs BNZ | PE, 0.96 (90% CI, 0.91–1.10) | PE, 084 (90% CI, 0.81–0.88) | PE, 0.83 (90% CI, 0.80–0.87) | ||
a
BNZ, benznidazole.
b
Cmax, maximum concentration; AUC0–t, area under the curve from time zero to the last measurement; AUC0–∞, area under the curve from time zero to infinity; t1/2, terminal half-life; tmax, time of Cmax; GM, geometric mean; CV%, coefficient of variation; PE, point estimate; CI, confidence interval.
c
n = 28, except for AUC0–∞ and t1/2, where n = 27.