TABLE 2.
P. falciparum genes encoding proteins prenylated by isoprenoids
| Gene ID (PF3D7_) | Name | Protein description | tpeak (h of IDC)a |
FCgeneb (SD) | |
|---|---|---|---|---|---|
| CTL | FOS | ||||
| 1319100 | Conserved DUF544 protein, unknown function | 0 | 0 | 1.00 (0.16) | |
| 1437900 | HSP40 | HSP40, subfamily A, putative | 20 | 23 | 1.32 (0.21) |
| 0322000 | CYP19A | Peptidyl-prolyl cis-trans isomerase | 23 | 25 | 1.84 (0.54) |
| 1113100 | PRL | Protein tyrosine phosphatase | 0 | 0 | 1.03 (0.14) |
| 1231100 | RAB2 | Ras-related protein, Rab2 | 8 | 13 | 4.01 (4.22) |
| 0106800 | RAB5c | Ras-related protein, Rab5c | 35 | 35 | 2.21 (0.65) |
| 1320600 | RAB11a | Ras-related protein, Rab11a | 48 | 48 | 1.31 (0.32) |
| 1340700 | RAB11b | Ras-related protein, Rab11b | 36 | 37 | 0.93 (0.22) |
| 0807300 | RAB18 | Ras-related protein, Rab18 | 20 | 24 | 0.94 (0.37) |
| 0513800 | RAB1a | Ras-related protein, Rab1a | 28 | 31 | 0.98 (0.28) |
| 0512600 | RAB1b | Ras-related protein, Rab1b | 8 | 40 | 3.05 (0.76) |
| 0211200 | RAB5a | Ras-related protein, Rab5a | 30 | 34 | 0.80 (0.27) |
| 1310600 | RAB5b | Ras-related protein, Rab5b | 41 | 41 | 0.98 (0.17) |
| 1144900 | RAB6 | Ras-related protein, Rab6 | 39 | 41 | 1.34 (0.40) |
| 0903200 | RAB7 | Ras-related protein, Rab7 | 32 | 32 | 0.76 (0.10) |
| 0910600 | YKT6.1 | SNARE protein, putative | 48 | 48 | 1.47 (0.23) |
| 1324700 | YKT6.2 | SNARE protein, putative | 40 | 7 | 1.23 (0.40) |
a
Hour (tpeak) of intraerythrocytic developmental cycle (IDC) when the gene was maximally expressed.
b
The fold-change value (FCgene) of a gene was computed as the ratio of the average gene-expression level under the treated condition to that under the untreated condition. Abbreviations: CTL, untreated; FOS, fosmidomycin-treated; SD, standard deviation.