TABLE 5.
P. falciparum genes involved in translational regulation
| Gene ID (PF3D7_) | Name | Protein description | tpeak (h of IDC)a |
FCgeneb (SD) | |
|---|---|---|---|---|---|
| CTL | FOS | ||||
| RNA-binding proteins | |||||
| 1359400 | CELF1 | CUGBP Elav-like family member 1 | 11 | 15 | 1.13 (0.21) |
| 1409800 | CELF2 | CUGBP Elav-like family member 2, putative | 0 | 19 | 2.35 (1.65) |
| 1346300 | ALBA2 | DNA/RNA-binding protein Alba 2 | 0 | 48 | 1.68 (0.79) |
| 1006200 | ALBA3 | DNA/RNA-binding protein Alba 3 | 22 | 25 | 0.83 (0.15) |
| 0417100 | PUF2 | mRNA-binding protein PUF2 | 0 | 0 | 0.48 (0.27) |
| CNOT complex | |||||
| 0107200 | CCR4-3 | Carbon catabolite repressor protein 4, putative | 13 | 26 | 1.12 (0.66) |
| 1434000 | CAF16 | CCR4-associated factor 16, putative | 0 | 15 | 6.85 (5.67) |
| 1128600 | NOT2 | CCR4-NOT transcription complex subunit 2, putative | 0 | 29 | 0.96 (0.32) |
| 1235300 | NOT4 | CCR4-NOT transcription complex subunit 4, putative | 0 | 4 | 0.94 (0.14) |
| 1006100 | NOT5 | CCR4-NOT transcription complex subunit 5, putative | 5 | 10 | 1.34 (1.00) |
| 0507600 | CAF40 | Cell differentiation protein, putative | 8 | 14 | 1.88 (0.45) |
| mRNA decapping | |||||
| 1308900 | DCP2 | mRNA decapping enzyme 2, putative | 10 | 15 | 0.80 (0.13) |
| 0819900 | LSM3 | U6 snRNA-associated Sm-like protein LSm3, putative | 11 | 25 | 0.98 (0.22) |
| 1443300 | LSM5 | U6 snRNA-associated Sm-like protein LSm5, putative | 8 | 11 | 5.19 (4.48) |
| 1209200 | LSM7 | U6 snRNA-associated Sm-like protein LSm7, putative | 14 | 24 | 1.28 (0.36) |
| 0829300 | LSM8 | U6 snRNA-associated Sm-like protein LSm8, putative | 12 | 22 | 1.62 (0.55) |
| mRNA degradation | |||||
| 0209200 | MTR3 | 3′ exoribonuclease, putative | 8 | 11 | 1.50 (0.62) |
| 1106300 | 5′–3′ exoribonuclease 1, putative | 24 | 30 | 0.75 (0.25) | |
| 0720000 | CSL4 | Exosome complex component CSL4, putative | 8 | 12 | 0.75 (0.13) |
| 0909900 | Helicase SKI2W, putative | 0 | 5 | 1.24 (0.09) | |
aHour (tpeak) of intraerythrocytic developmental cycle (IDC) when the gene was maximally expressed.
b
The fold-change value (FCgene) of a gene was computed as the ratio of the average gene-expression level under the treated condition to that under the untreated condition. Abbreviations: CNOT, carbon catabolite repression—negative on TATA-less; CTL, untreated; FOS, fosmidomycin-treated; SD, standard deviation.