TABLE 2.
Fractional inhibitory concentration index (FICi) of SPR719 in combination with established antimycobacterial drugs against M. abscessus, MAC, and M. kansasiia
| Species | Mean FICi (range) of SPR719 combinations with: |
||||||
|---|---|---|---|---|---|---|---|
| CLR | CFZ | EMB | RIF | FOX | TIG | AMK | |
| MAC (n = 10) | 1.3 (1 to >2) | 1.2 (0.8–1.5) | 0.8 (0.5–1.5) | 1.2 (0.6–1.5) | NR | NR | 1.4 (1–1.5) |
| M. kansasii (n = 6) | 1.5 (1–1.5) | NR | 0.8 (0.5–1.5) | 1.3 (0.5–1.5) | NR | NR | 1.4 (0.6–1.5) |
| M. abscessus (n = 5) | 0.8 (0.5–1) | 1.1 (0.8–1.5) | NR | NR | 1.4 (1–1.5) | 0.8 (0.5–1) | 1.5 (1.5) |
a
MAC, M. avium complex; CLR, clarithromycin; CFZ, clofazimine; RIF, rifampicin; EMB, ethambutol; AMK, amikacin; TIG, tigecycline; FOX, cefoxitin; NR, not relevant to this species.