TABLE 3.
Response surface analysis results of time-kill data, as well as interaction effect size, by deviation from expected combination effect under Bliss independence in percent ΔE
| Combination (concn) | SPR719 | Effect (log10 CFU/mL × day) |
|||
|---|---|---|---|---|---|
| Companion | Observed, combination | Expected, combinationa | ΔE (%) | ||
| M. avium | |||||
| SPR719/ethambutol (2× MIC) | 88.1 | 165 | 116 | 116 | 0.49 |
| SPR719/ethambutol (1× MIC) | 86.3 | 122 | 120 | 109 | 9.80 |
| SPR719/ethambutol (0.5× MIC) | 84.0 | 98.9 | 100 | 104 | −3.77 |
| M. kansasii | |||||
| SPR719/ethambutol (2× MIC) | 101 | 184 | 128 | 108 | 19.0 |
| SPR719/ethambutol (1× MIC) | 103 | 168 | 146 | 106 | 37.4 |
| SPR719/ethambutol (0.5× MIC) | 109 | 94.3 | 184 | 105 | 74.8 |
| M. abscessus | |||||
| SPR719/clarithromycin (2× MIC) | 23.1 | 8.44 | 34.7 | 20.9 | 65.9 |
| SPR719/clarithromycin (1× MIC) | 22.6 | 5.42 | 31.5 | 21.4 | 47.6 |
| SPR719/clarithromycin (0.5× MIC) | 14.0 | 4.63 | 23.7 | 15.1 | 56.6 |
a
Under Bliss independence.