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. 2021 Mar 18;65(4):e02004-20. doi: 10.1128/AAC.02004-20

FIG 3.

FIG 3

(A and B) Viable bacterial counts of E. coli BW25113 with recA gene and katG detoxification system inactivation alone or in combinations in time-kill assays at (A) ciprofloxacin (CIP) concentrations of 4× MIC of each strain (normalized MICs, 0.06 mg/liter for BW25113 and ΔkatG, 0.015 mg/liter for ΔrecA, and 0.004 mg/liter for ΔkatG ΔrecA) at 0 h, 4 h, and 8 h and (B) ciprofloxacin concentrations of 4× MIC and 8× MIC of each strain (normalized MICs, 0.125 mg/liter for BW25113 and ΔkatG, 0.03 mg/liter for ΔrecA, and 0.008 mg/liter for ΔkatG ΔrecA) and the nonantibiotic control at 4 h. Data are represented as the means of at least three independent measurements. Standard deviations are shown. CIP, ciprofloxacin. Significant P values are noted (*, P < 0.05; ***, P < 0.001).