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. 2021 Mar 18;65(4):e01146-20. doi: 10.1128/AAC.01146-20

FIG 4.

FIG 4

Arbidol synergizes with aripiprazole to suppress arenaviruses. All data were analyzed by SynergyFinder2. Error bars represent the averages of the standard deviations of the overall Bliss synergy scores. (A) Representative pseudovirus results. For LASV, data are derived from a single experiment with a Z score of 0.74 and a signal-to-noise ratio of 33,139. The 1× concentrations of Arb, Amo, and Ari were 11, 8, and 12 μM, respectively. For JUNV, data are derived from a single experiment with a Z score of 0.29 and a signal-to-noise ratio of 34,193. The 1× concentrations of Arb, Amo, and Ari were 8, 12, and 5 μM, respectively. (B) Data reflecting the composite from 8 and 6 separate experiments performed using drug combination assay 1 for LASV and JUNV, respectively. The indicated P values are derived from one-way ANOVA using Tukey’s multiple-comparison test in GraphPad Prism. P values for all other comparisons were >0.05. Data represent averages and standard deviations from triplicate conditions for each drug combination (A), while the triplicate data in each experiment were averaged across the eight LASV and six JUNV experiments (B).