FIG 6.

Combining arbidol with sertraline causes synergistic suppression of JUNV and LASV pseudoviruses. Vero cells were treated with the indicated concentrations of arbidol and sertraline before mock infection or infection with MLV pseudoviruses expressing JUNV (A) or LASV (B) GP; virus infection and cell viability were quantified as described in Materials and Methods. Concentration-response matrices for virus-infected cells were analyzed in SynergyFinder2, which reports the average Bliss synergy score calculated over the full matrix (synergy score) and the maximum Bliss synergy over the maximum synergistic area (MSA) (dotted-line squares). Selective efficacy quantifies the difference between inhibition of virus-infected (virus) and mock-infected (viability) cells.