TABLE 4.

Mutations in genes associated with resistance to the azoles and echinocandins detected among the Candida auris isolates from the SENTRY program

Study yr	Country, State (hospital [H] 1 or 2)	MIC (mg/liter)				Amino acid alterationsa
		Anidulafungin	Fluconazole	Isavuconazole	Voriconazole	CDR1	ERG11	ERG3	FKS1	UPC2
2009	Germany	0.5	>64	0.06	0.5	S21L	S74L, A25L, F126L	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L
2013	NY (H1), USA	0.5	>128	0.5	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L
2014	Colombia	1	64	1	1	S21L, H771R	S74L, K177R, N335S, E343D, Y501H	S58T	S906L	S36L, S89L, I223M, S237L, S376L, S436L, S456L
2015	NJ, USA	0.5	>128	0.5	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L
2016	NY (H2), USA	0.5	>128	0.5	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L
2016	NY (H2), USA	0.5	>128	0.5	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L
2017	NY (H1), USA	0.25	>128	0.5	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L
2018	NJ, USA	0.5	>128	0.5	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S376L, S436L, S456L
2018	NY (H2), USA	0.5	>128	1	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S237L, S89L, S376L, S436L, S456L
2018	NY (H2), USA	0.5	>128	0.5	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L
2018	NY (H2), USA	0.5	>128	1	2	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L
2018	NY (H2), USA	0.5	>128	1	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L
2018	Panama	0.25	16	0.06	0.06	S21L	S74L, K177R, N335S, E343D	S58T	S906L	S36L, S89L, I223M, S237L, S376L, S436L, S456L
2018	Panama	0.25	4	0.03	0.03	S21L	S74L, K177R, N335S, E343D	S58T	S906L	S36L, S89L, I223M, S237L, S376L, S436L, S456L
2019	NJ, USA	0.5	>128	0.5	1	S21L, V704L	S74L, K143R	WT	S906L	S36L, S89L, S237L, S376L, S436L, S456L

^aMutations in boldface have previously have been shown to cause resistance.