TABLE 2.
Experimental design for C3HeB/FeJNju mouse model. Dosing schedule: loading doses (5/7) for 2 weeks for all treatment groups, dosing days per week (5/7 for QD, 3/7 for TIW) after loading dose
| No. of mice sacrificed in each group |
Total no. of mice | ||||||
|---|---|---|---|---|---|---|---|
| Groups | Drug | D-28a | D-14 | D0 | W4b | W8 | |
| Control | Untreated | 3 | 3 | 3 + 3 | 5 + 3 | 5 + 3 | 28 |
| QD | CLO | 5 + 3 | 5 + 3 | 16 | |||
| TIW | CLO | 5 + 3 | 5 + 3 | 16 | |||
| QD | TBI-166 | 5 + 3 | 5 + 3 | 16 | |||
| TIW | TBI-166 | 5 + 3 | 5 + 3 | 16 | |||
| Total no. of mice | 3 | 3 | 6 | 40 | 40 | 92 | |
a
D, day sacrificed.
b
W, weeks treated.