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| Compound | Concentration (μM) | Test species | NADPH-dependent CLint† (μl/min/mg) | NADPH-dependent T1/2‡ (min) | NADPH-free CLint† (μl/min/mg) | NADPH-free T1/2‡ (min) |
|---|---|---|---|---|---|---|
| 1 | 1 | Human | 15.5 | 149 | <12.8 | >180 |
| Verapamil | 1 | Human | 135 | 17.1 | <12.8 | >180 |
| Dextromethorphan | 1 | Human | 24.2 | 95.3 | <12.8 | >180 |
Microsomal intrinsic clearance = ln(2)/(T1/2 [microsomal protein]).
Half-life = 0.693/-k.
