Table 2.
Adjusted hazard ratios for mortality in stage II colon cancer based on patient and tumor features.
| Variable | HR (95% CI) | p-value |
|---|---|---|
| MSI-H (vs MSS/MSI-L) | 0.75 (0.65-0.87) | <0.001 |
| Age (SD) | 1.06 (1.05-1.06) | <0.001 |
| Female (%) | 0.78 (0.72-0.85) | <0.001 |
| Race | ||
| White | Ref | Ref |
| Black | 1.29 (1.14-1.46) | <0.001 |
| Other | 0.69 (0.56-0.87) | <0.001 |
| Institution type | ||
| Community Cancer Program | Ref | Ref |
| Comprehensive Community Program | 0.88 (0.76-1.10) | 0.066 |
| Academic/Research | 0.80 (0.69-0.93) | 0.003 |
| Integrated Network Cancer Program | 0.89 (0.76-1.05) | 0.170 |
| Primary Payor | ||
| Not insured | Ref | Ref |
| Private insurance | 0.72 (0.55-0.95) | 0.022 |
| Medicaid | 1.21 (0.88-1.67) | 0.247 |
| Medicare | 0.89 (0.67-1.17) | 0.404 |
| Other Government | 0.99 (0.60-1.64) | 0.961 |
| Unknown | 0.96 (0.59-1.57) | 0.873 |
| Charlson-Deyo score | ||
| 0 | Ref | Ref |
| 1 | 1.22 (1.12-1.34) | <0.001 |
| 2 | 1.83 (1.62-2.08) | <0.001 |
| 3+ | 2.61 (2.23-3.05) | <0.001 |
| Primary Tumor Site | ||
| Left colon/rectosigmoid | Ref | Ref |
| Right colon | 0.89 (0.82-0.97) | 0.005 |
| Adjuvant chemotherapy | 0.90 (0.80-1.02) | 0.096 |
| T4 Stage | 1.77 (1.59-1.96) | <0.001 |
| Lymphovascular Invasion | ||
| Absent | Ref | Ref |
| Present | 1.19 (1.06-1.33) | 0.003 |
| Unknown | 1.09 (0.92-1.30) | 0.331 |
| Perineural Invasion | ||
| Absent | Ref | Ref |
| Present | 1.40 (1.22-1.60) | <0.001 |
| Unknown | 1.01 (0.81-1.27) | 0.921 |
| Tumor Grade | ||
| Low Grade | Ref | Ref |
| High Grade | 1.12 (0.99-1.24) | 0.052 |
| Unknown | 1.03 (0.78-1.36) | 0.826 |
| Positive Margins | 1.36 (1.18-1.57) | <0.001 |
| < 12 Lymph Nodes | 1.27 (1.11-1.45) | <0.001 |