Table 3.
Adjusted hazard ratios for mortality from stage II colon cancer based on MSI status
| MSS/MSI-L | MSI-H | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | p-value | HR (95% CI) | p-value |
| Adjuvant chemotherapy | 0.87 (0.76-0.97) | 0.027 | 1.42 (0.91-2.24) | 0.124 |
| T4 Stage | 1.72 (1.04-1.32) | 0.008 | 2.61 (1.83-3.72) | <0.001 |
| Lymphovascular Invasion | ||||
| Absent | Ref | Ref | Ref | Ref |
| Present | 1.22 (1.09-1.38) | 0.001 | 0.90 (0.59-1.37) | 0.625 |
| Unknown | 1.15 (0.96-1.38) | 0.123 | 0.67 (0.36-1.25) | 0.212 |
| Perineural Invasion | ||||
| Absent | Ref | Ref | Ref | Ref |
| Present | 1.44 (1.26-1.66) | <0.001 | 1.14 (0.63-2.05) | 0.671 |
| Unknown | 0.92 (0.72-1.17) | 0.499 | 2.06 (1.13-3.76) | 0.018 |
| Tumor Grade | ||||
| Low Grade | Ref | Ref | Ref | Ref |
| High Grade | 1.18 (1.04-1.32) | 0.008 | 0.86 (0.63-1.17) | 0.333 |
| Unknown | 0.95 (0.70-1.29) | 0.733 | 1.82 (0.87-3.78) | 0.111 |
| Positive Margins | 1.33 (1.14-1.54) | <0.001 | 1.73 (1.07-2.80) | 0.025 |
| < 12 Lymph Nodes | 1.26 (1.09-1.44) | <0.001 | 1.56 (0.82-2.95) | 0.173 |
*
Cox regression adjusting for age, sex, race, institution type, primary payor, Charlson-Deyo score, and tumor side