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. 2021 Apr 21;12:623979. doi: 10.3389/fphar.2021.623979

TABLE 5.

Associations between motivations, ceremony characteristics and additional supports and mental health outcomes.

PWG e SF-12 MCS f Kessler 10 g PGIC anx/dep h
B (SE) P = B (SE) P = B (SE) P = B (SE) P =
Covariates
 Age (decades) −0.67 (0.1) 0.000 0.81 (0.1) 0.000 −0.37 (0.05) 0.000 −0.03 (0.02) 0.148
 Female 0.55 (0.24) 0.023 −1.24 (0.23) 0.000 0.7 (0.12) 0.000 −0.01 (0.05) 0.825
 University educ −1.57 (0.25) 0.000 −1.48 (0.25) 0.000 0.45 (0.13) 0.000 −0.09 (0.05) 0.077
 Lifetime MH diagnoses a 0.21 (0.12) 0.087 −1.05 (0.11) 0.000 0.73 (0.06) 0.000 0 (0.02) 0.994
 Num drunk b 1.2 (0.06) 0.000 0.53 (0.06) 0.000 −0.24 (0.03) 0.000 0.1 (0.01) 0.000
 Years since drunk c −0.03 (0.03) 0.253 −0.07 (0.03) 0.019 0.02 (0.02) 0.208 −0.02 (0.01) 0.011
Motivations
 Therapeutic 0.35 (0.11) 0.001 −0.69 (0.11) 0.000 0.43 (0.05) 0.000 −0.01 (0.02) 0.687
 Self−knowledge 0.48 (0.1) 0.000 0.07 (0.1) 0.466 −0.15 (0.05) 0.005 0.03 (0.02) 0.170
 Experiential −0.65 (0.11) 0.000 −0.37 (0.1) 0.000 0.33 (0.06) 0.000 −0.06 (0.02) 0.011
Ceremony characteristics
 Traditional −0.22 (0.12) 0.071 −0.19 (0.11) 0.090 0.16 (0.06) 0.005 0.05 (0.02) 0.031
 Non−traditional 0.12 (0.12) 0.327 −0.02 (0.12) 0.875 −0.05 (0.06) 0.372 0.01 (0.02) 0.706
 Religious −0.12 (0.31) 0.700 0.13 (0.32) 0.679 0.05 (0.16) 0.757 0.01 (0.06) 0.913
 Support and safety 1.91 (0.25) 0.000 1.5 (0.23) 0.000 −0.62 (0.12) 0.000 0.07 (0.05) 0.181
 Traditional countries d −0.35 (0.48) 0.473 0.58 (0.46) 0.205 −0.47 (0.22) 0.035 −0.17 (0.09) 0.052
Additional supports
 Preparation activities score 0.75 (0.14) 0.000 0.45 (0.14) 0.002 −0.25 (0.07) 0.001 0.13 (0.03) 0.000
 Religious/spiritual couns 1.18 (0.29) 0.000 0.72 (0.28) 0.012 −0.28 (0.15) 0.056 0.06 (0.06) 0.370
 Psychologist/psychotherapist 0.59 (0.68) 0.382 1.39 (0.69) 0.044 −0.71 (0.35) 0.042 0.06 (0.12) 0.636
 Yoga/tai−chi etc 0.96 (0.44) 0.028 0.93 (0.43) 0.031 −0.71 (0.22) 0.001 0.06 (0.08) 0.431
 Fasting 0.97 (0.37) 0.008 0.6 (0.39) 0.129 −0.28 (0.21) 0.183 0.09 (0.07) 0.182
Prob > F (n) p < 0.000 (6,877) p < 0.000 (6,877) p < 0.000 (6,877) p < 0.000 (1,278)
a

Number of lifetime mental health diagnoses.

b

Lifetime uses of ayahuasca (categories as per Table 1).

c

Number of years since last drank ayahuasca.

d

Countries include all Amazonian countries where ayahuasca has been used traditionally by indigenous groups except Brazil (Peru, Ecuador, Colombia, Bolivia and Venezuela).

e

Perceived growth in psychological wellbeing.

f

Current mental health status.

g

Psychological distress.

h

Reported change in prior clinically diagnosed anxiety or depression.