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Brain CYP2D and UGT2B7 mediate the metabolism of codeine and morphine. CYP2D catalyzes the demethylation of codeine into morphine. UGT2B7 mediates the glucuronidation of positions 3 and 6 of the hydroxyl groups of morphine into M3G and M6G. CYP2D, Cytochrome P450 2D; UGT2B7, UDP-glucuronosyltransferase 2B7; M3G, morphine-3-glucuronide; M6G, morphine-6-glucuronide.
